Antipsychotic Use in Youths with ADHD is Low, but Still Cause for Concern
Jim Liebelt Jim Liebelt's Blog
- 2019 Jul 29
*The following is excerpted from an online article posted on MedicalXpress.
Although fewer young people with ADHD are treated with antipsychotic drugs than suspected, many prescriptions for the drugs do not appear to be clinically warranted, according to a new study from psychiatry researchers at Columbia University Vagelos College of Physicians and Surgeons. They also found that antipsychotic use among youths with ADHD was highest among preschool-age children.
In recent years, pediatricians and parents have expressed concern that some physicians are prescribing antipsychotic drugs to youths with ADHD who have significant aggressive or impulsive behavior. Youths with ADHD who are treated with antipsychotics are often also diagnosed with depression, oppositional defiant disorder (ODD), or conduct disorders (CD), even though there is limited evidence that the drugs are effective for ODD or CD and no evidence they are effective in treating depression.
"We didn't know how widespread this practice was among young people starting ADHD treatment," says senior author Mark Olfson, MD, MPH, Elizabeth K Dollard Professor of Psychiatry, Medicine, and Law at Columbia University Vagelos College of Physicians and Surgeons. "There are substantial risks associated with the use of antipsychotic drugs in young people, including weight gain, hyperlipidemia, diabetes, and even unexpected death."
To determine the prevalence of antipsychotic use in youths with ADHD, the researchers analyzed medical and prescription drug data on 187,563 commercially insured youths (ages 3 to 24) who were diagnosed with ADHD between 2010 and 2015. None of the youths had a recent coexisting psychiatric diagnosis (such as schizophrenia or bipolar disorder) that would warrant treatment with antipsychotic drugs.
The researchers found that 2.6% of youths diagnosed with ADHD were prescribed an antipsychotic drug within a year of diagnosis--four times the rate among young people in general. Antipsychotic drug use was highest (4.3%) in the youngest children diagnosed with ADHD, those aged 3-5 years.
In about half of those taking antipsychotic drugs, the researchers identified a potential diagnostic rationale--such as bipolar disorder, psychosis, ODD, or CD--for prescribing them.
The study also found that fewer than half of the children and adolescents taking antipsychotic drugs had been treated first with stimulants such as Adderall and Ritalin, the recommended medication treatment for ADHD.
"Many physicians bypassed stimulants and went right to antipsychotics--contrary to expert opinion about treatment for ADHD, and unnecessarily exposing patients to the risk of severe side effects such as substantial weight gain," adds Sultan.